Aug 2026· Molecular and Cellular Biochemistry· Vol 481, pp. 4657 - 4671· 0 citations· 50 references
Medicine
TL;DR
It is demonstrated that GALNT6-glycosylated LRG1 mediates the interaction between M2 macrophages and PC cells by activating CCR1, which may provide promising therapeutic targets for PC treatment.
HIST1H4L was significantly upregulated in SCLC tumors versus normal tissues and enriched in DNA transcription-related pathways and correlated with poor patient survival; critically, high HIST1H4L expression correlated with poor patient survival.
Shi-Cheng Feng, Min Feng, Zhi-Qiang Lu et al.· Frontiers in Oncology· 0 citations
Clinically, these findings identify the METTL1/USP48/LCN2 pathway as a potential therapeutic target for cSCC and elucidated a novel oncogenic axis in cSCC, wherein METTL1 stabilized USP48 mRNA through m7G methylation modification, and USP48 in turn deubiquitinated and stabilized LCN2 protein.
Xiu-Qi Li, Lin Shu, Xiao-Qiang Li et al.· Applied Biochemistry and Bio...· 0 citations
It is suggested that GNAS-AS1 may contribute to the maintenance of M2-like characteristics in TAMs and facilitate CC progression, potentially through a mechanism involving miR-518c-5p sequestering, FBXO38 upregulation, and subsequent modulation of MAPK signaling.
Li-Li Zhang, Fang Zhao, Lin Zhang et al.· Molecular Carcinogenesis· 0 citations
A specific mechanism whereby HOXC9 transcriptionally activates NRP1 is elucidated, thereby contributing to CRC malignant development and immune evasion and elucidate a specific mechanism whereby NRP1 overexpression could reverse CRC progression inhibition and immune function enhancement caused by HOXC9 downregulation.
Xiaofeng Qiu, Sheng Hu, Bingling Liao et al.· Zeitschrift für Induktive Ab...· 0 citations
By hindering the Wnt/β-catenin pathway, overexpression of FBXO17 promotes ferroptosis and subsequently inhibits the malignant phenotype and stemness properties of PCa cells.
