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Astrocytes instructively regulate neuronal translation

Wendy J Liu Carson C Schultz Eshaan A Khan Mauricio M. Oliveira S. Kalavai Charles J. Sheehan Xunzhao Zhang Richard Sam E. Klann

Jul 2026 · bioRxiv · 0 citations · 113 references

Medicine Biology

TL;DR

It is shown that astrocyte-secreted proteins regulate global neuronal translation depending on astrocytic state, and astrocyte-secreted signals required neuronal endocytosis to influence translation and drove synaptic remodeling dependent on glutamatergic signaling and neuronal mTORC1 activity.

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