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Cdc42 small GTPase is a novel regulator of the fibrogenic activation of human intestinal myofibroblasts

Atif Zafar Gaurav Chauhan Pranab K. Mukherjee Armando Marino-Melendez Ryan Musich Yan Wang N. Naydenov Florian Rieder A. Ivanov

Jul 2026 · bioRxiv · 0 citations

Biology Medicine

TL;DR

Cdc42 is highlighted as a key regulator of intestinal fibrosis that controls mTOR activation to enhance ECM production and contractile actomyosin cytoskeleton in intestinal myofibroblasts.

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