The mediating role of inflammation and nutrition metabolism in the methylmalonic acid-stroke association

Abstract

Highlights • Elevated MMA levels are associated with increased stroke risk in US adults.• Restricted cubic spline analysis identified a nonlinear relationship between MMA and stroke, with a cutoff at ln (MMA = 5).• The MMA-stroke correlation is stronger in younger adults than in older adults (P for interaction = 0.013).• Combined detection of NLR, TG, and FPG may help identify populations at elevated stroke risk in this cross-sectional exploratory analysis.