Jul 2026· npj Metabolic Health and Disease· Vol 4· 0 citations· 20 references
Medicine
TL;DR
This commentary highlights the growing burden of lean MASLD, the importance of visceral adiposity and cardiometabolic dysfunction, and population-specific genetic influences in Indian populations.
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) in India demonstrates marked regional variation influenced by metabolic risk, lifestyle transition, and population-specific susceptibility. This commentary highlights the growing burden of lean MASLD, the importance of visceral adiposity and cardiometabolic dysfunction, and population-specific genetic influences in Indian populations. Given the close association between MASLD and type 2 diabetes, region-specific prevention, early risk assessment, and integrated metabolic care strategies are increasingly important.
Metabolic dysfunction–associated steatotic liver disease (MASLD) is linked to insulin resistance and cardiometabolic disorders. This review synthesizes current information on the epidemiology, pathophysiology, and treatment of MASLD and its progressive form, metabolic dysfunction– associated steatohepatitis (MASH), und...
Risheng Xu, N. Abate, R. Stribling et al.· Cleveland Clinic journal of...· 0 citations
A critical review of the current literature regarding the Lean MASLD phenotype, with particular emphasis on its metabolic heterogeneity, indicates a significant role of genetic variants, mainly the PNPLA3 polymorphism (I148M), which predisposes lean individuals to disease progression independently of metabolic factors.
Julia Popielska, Sabina Zima, Bartosz Stawarski et al.· International Journal of Inn...· 0 citations
Metabolic dysfunction-associated steatotic liver disease is now recognized as a multisystem metabolic disorder rooted in insulin resistance, shifting the frontline of care from hepatologists to endocrinologists. Endocrinologists act as "gateway specialists," managing cardiovascular and metabolic complications in low-ri...
Md. Shahed-Morshed· Journal of Association of Cl...· 0 citations
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of liver disease worldwide. It is associated with metabolic syndrome and contributes to increased cardiovascular risk. The main focus of management revolves around weight loss and lifestyle modification, while therapeutic options remain...
Janet Cao, Avik Majumdar, A. Testro et al.· Dietetics· 0 citations
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent metabolic disorder characterized by substantial clinical heterogeneity and frequent association with obesity, insulin resistance, type 2 diabetes mellitus, dyslipidemia, visceral adiposity, and alterations in body composition. This s...
Cristian Arturo Abia-Meashima, Gil Alejandro Garrido Echeverria, María Cristina Martínez Mazón et al.· IECCMEXICO· 0 citations
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