TL;DR
Overall, PLD effectively reduced neurodegeneration in the hippocampus of diabetic rats via inhibiting oxidative stress, inflammation, and Aβ1−42 accumulation and may act as a promising multi-target anti-neurodegenerative candidate.
Results support modulation of the Nrf2/KEAP1 pathway as a mechanism contributing to the neuroprotective actions of Met and identify the coordinated enhancement of antioxidant defenses and reduction of lipid peroxidation as key components of neuronal redox resilience against AβOs-induced stress.
The findings suggest that trigonelline protects brain against alcohol intoxication by inhibition of oxidative and inflammatory and apoptotic responses, and may serve as a potential therapeutic approach for the protection of brain damage associated with binge alcohol consumption.
ZnSO4 supplementation provides potent, multifaceted neuroprotection against T2DM-associated neurodegeneration by regulating systemic dyslipidemia, restoring redox homeostasis, activating the SIRT-1/BDNF anti-apoptotic pathway, and preserving structural integrity.
BLN exhibits considerable neuroprotective properties against CIS‐induced neurotoxicity in the hippocampus, suggesting its potential as a natural dietary phytonutrient supplement to ameliorate chemotherapy‐induced cognitive impairment.
Liquiritigenin protects against neuroinflammation and mitochondrial impairment by suppressing NF-κB signaling, thereby mitigating neurological dysfunction in HSD-related neurological disorders.
Santonin helps reverse the brain changes and behavior problems caused by AlCl 3 in rats, and it looks promising as a neuroprotective agent for AD.
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
