Neuroprotective Effects of lncRNA EPB41L4A-AS1 Against Ischemic Stroke Injury Through Regulating Microglial State Transition and Ferroptosis via miR-214-3p/GPX4 Axis

LncRNA UCA1 Aggravated Microglia-mediated Neuroinflammation After Traumatic Brain Injury by Targeting miR-708-5p

MiR-590-3p Targets HMGB1 to Alleviate Endothelial Injury Induced by β2GPI/Anti-β2GPI Immune Complex.

BACKGROUND As a systemic autoimmune condition, antiphospholipid syndrome (APS) currently lacks robust biomarkers for accurate diagnosis. While microRNAs (miRNAs) show promise as diagnostic and therapeutic targets, the specific function of miR-590-3p in APS pathogenesis is still unknown. OBJECTIVE This study investiga...

Study on the Expression of MiR-642b-3p in Spontaneous Intracerebral Hemorrhage and Its Regulatory Mechanism on Endothelial Cell Injury

MiR-642b-3p is upregulated in sICH and mediates thrombin-induced endothelial cell injury, at least in part, by targeting CCNA2.

Exosomal miR-223-3p, associated with NLRP3-related neuroinflammation, as a potential biomarker for mild cognitive impairment in patients with type 2 diabetes mellitus.

BackgroundNeuroinflammation has been implicated in diabetic cognitive dysfunction, with the NLRP3 playing an important role.ObjectiveThis study aimed to elucidate the regulatory role of miR-223-3p in NLRP3 associated neuroinflammation and its potential as a biomarker for mild cognitive impairment (MCI) in type 2 diabet...

Protective effect of miR-642b-3p against brain injury after intracerebral hemorrhage by targeting SERPINE1.

The findings support that restoration of miR-642b-3p alleviates post-ICH cerebral edema and neurological deficits via targeted inhibition of SERPINE1-mediated inflammation, involving suppression of NLRP3 inflammasome and promotion of M2 polarization.

lncRNA TUG1 mediates palmitic acid-induced neuronal lipotoxic injury via the miR-449a-5p/caspase-3 and Akt/GSK-3β axes

Findings establish a causal axis in which lncRNA TUG1 derepresses caspase-3 and suppresses Akt/GSK-3β signaling by sponging miR-449a-5p, thereby driving neuronal lipotoxic injury.