Overall, organoid technology represents a promising approach for precision medicine, personalized therapy, and next-generation drug development and continued development of standardized culture systems and multicellular organoid platforms may improve reproducibility and regulatory acceptance.
INTRODUCTION
High translational failure rates and ethical concerns surrounding animal models are driving the development of technologies to improve the drug development process. Organoids, three-dimensional self-organizing structures derived from stem cells, provide scalable, human-relevant platforms that recapitulate...
Jolene Phelps, Amanda Orr, Stephanie M. Willerth· Expert Opinion on Drug Disco...· 0 citations
Current progress and future directions in organoid research are delineated, furnishing a theoretical foundation and guiding future investigations towards enhancing personalized treatment paradigms.
Xin-Kui Zhou, Xing-Xue Yan, Zheng-Yang Zhang et al.· Frontiers in Cell and Develo...· 0 citations
This review introduces the sources and isolation methods of stem cells for lung organoid generation, describes preparation processes, and evaluates the utility of lung organoids in building pulmonary disease models, distinguishing between current validated applications and proposed future capabilities.
Lu-Yu Yang, Yuan-Fang Xing, Jia-Yi Chen et al.· World Journal of Stem Cells· 0 citations
This review summarizes recent advances in 3D cardiac in vitro modeling technologies, outlines major cardiac model construction strategies and their technical characteristics, and discusses their applications in drug toxicity evaluation, high-throughput drug screening, disease modeling, and personalized medicine.
Xiao-Ying Liu, Ying-Juan Liu, Yu-Tong Yan et al.· International Journal of Dru...· 0 citations
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development a...
Yue-Qi Leng, Yue Wang, C. Cao et al.· MedComm· 0 citations
The present narrative review outlines the scientific foundations underpinning organoid development, tracing their emergence from advances in tissue engineering and three-dimensional culture systems, and places particular emphasis on their growing role in precision medicine.
Maddalena Paganucci· The biochemist· 0 citations
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