Open access
A plasma‐based protein signature combining NPTXR, ACHE, and p‐tau217 predicts progression to symptomatic Alzheimer's disease
Menghan Liu
Katherine Gong
Yike Chen
Gyujin Heo
Ying Xu
J. Timsina
D. Western
J. Budde
J. Morris
Giorgetti Marco
David M. Holtzman
J. Hinson
Scott Levin
N. Ashton
M. Denkinger
Suzanne E. Schindler
Kausik Das
Muhammad Ali
C. Cruchaga
Medicine
Abstract
We recently identified a plasma‐based seven‐protein model with strong performance for Alzheimer's disease (AD) classification. Here, we evaluated whether these proteins, alone or combined with plasma phosphorylated tau 217 (p‐tau217), predict progression from cognitively unimpaired to symptomatic AD.