Open access
Elucidating the neuropathological and molecular heterogeneity of amyloid beta and tau in Alzheimer's disease through machine learning and transcriptomic integration
K. Zhao
Hua Xie
Tovia Jacobs
Naomi L. Gaggi
J. Fortea
Nancy B. Carlisle
G. Fonzo
K. Pohl
Ricardo S. Osorio
Yu Zhang
Medicine
Abstract
Functional brain network alterations associated with Alzheimer's disease (AD) pathology, including amyloid beta (Aβ) and phosphorylated tau (p‐tau), are difficult to interpret due to overlapping aging‐associated and non‐amyloid biological processes.