Aug 2026· TIPS - Trends in Pharmacological Sciences· Vol 47, pp. 955 - 958· 0 citations· 18 references
Medicine
TL;DR
Selective targeting of circulating amyloidogenic amylin and its pathogenic signaling may enable biomarker development and disease-modifying therapies, and enable biomarker development and disease-modifying therapies.
Abstract
Recent studies identify amyloidogenic human amylin, secreted from pancreas, as a potential link between type-2 diabetes and Alzheimer’s disease. Evidence suggests that pathogenic amylin signaling impairs cerebral bioenergetics, promoting tau hyperphosphorylation and neurodegeneration. Selective targeting of circulating amyloidogenic amylin and its pathogenic signaling may enable biomarker development and disease-modifying therapies.
The contemporary version of the most widely accepted model of Alzheimer's disease (AD), the β-amyloid cascade hypothesis, identifies β-amyloid oligomers as the primary neurotoxic species. Arising either from genetic mutations or environmental and lifestyle predisposing factors (collectively termed the ex-posome), β-amy...
D. Lim, L. Tapella· Journal of Neurochemistry· 0 citations
Evidence supports a shift from a linear amyloid model to a multidimensional framework and offers promise for early detection, risk stratification, and personalized multi-target therapies in AD.
C. D. Souza, Shiva Murthy Nanjundappa, N. Murali· International Journal of Bas...· 0 citations
: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and a growing public health concern. Its core pathological features include cerebral amyloid-β deposition and tau aggregation. mRNA translation is a tightly regulated process essential for gene expression and protein synthesis. It plays critical rol...
Ling Li, Fang-Yu Dai, Hai-Peng Liu et al.· Clinical Interventions in Ag...· 0 citations
There is a need for early, objective markers of Alzheimer's disease (AD)‐related synapse dysfunction in adults with Down syndrome (DS). The presynaptic protein β‐synuclein is elevated in the blood of adults with DS. This study evaluates the positioning of these changes relative to changes in pathophysiological blood bi...
Alba Cervantes González, A. Morcillo-Nieto, Sara Serrano et al.· Alzheimer's & Dementia· 0 citations
A variety of evidence now supports two interrelated hypotheses concerning Alzheimer’s disease (AD) neurofibrillary pathology (NFT), its prevention and treatment. The first hypothesis: the receptor type protein tyrosine phosphatase D (PTPRD) plays a key role in AD NFT pathogenesis by modulating activities of neuronal gl...
George R. Uhl, Joungil Choi, B. Kannan et al.· Biomedicines· 0 citations
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