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Unique transcriptomic alterations in 5XFAD;PS19 mouse model identify glial lipid dysregulation and coordinated microglial–oligodendrocyte responses

Jung Hyun Park Byungwook Kim Mamun Md Al‐Amin M. Tate A. D. Sharify Sutha K. John Hande Karahan Hui-Chen Lu L. Dabin Jungsu Kim
Aug 2026 · Alzheimer's & Dementia · Vol 22 · 0 citations · 72 references
Medicine

Abstract

Alzheimer's disease (AD) features amyloid beta (Aβ) plaques and tau tangles, yet how their coexistence reshapes brain transcriptomic programs remains unclear.

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