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Inhibition of Moesin and CD44 in stem cell‐derived neurons affects the pathological genetic signature associated with Alzheimer's disease

Eiden H. Brewer Charles A. Williams Gregory A. Cary R. Betarbet I. Pranoto E. Zoeller Haian Fu Allan I. Levey Jesse C Wiley Gregory W. Carter Jessica E. Young
Aug 2026 · Alzheimer's & Dementia · Vol 22 · 0 citations · 54 references
Medicine

TL;DR

Using human induced pluripotent stem cells (hiPSCs)‐derived neurons, human induced pluripotent stem cells were assayed how reducing gene expression of MSN and CD44 affected amyloid beta secretion, tau phosphorylation, and transcriptional state.

Abstract

Post mortem proteomic analysis of Alzheimer's disease (AD) brain tissue has identified novel target genes and proteins for potential therapeutic development. Moesin (MSN) and CD44 were identified as candidate targets. Using human induced pluripotent stem cells (hiPSCs)‐derived neurons, we assayed how reducing gene expression of MSN and CD44 affected amyloid beta secretion, tau phosphorylation, and transcriptional state.

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