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Dissecting Alzheimer's proteomic landscape through NULISA profiling of brain cell‐specific extracellular vesicles

Ashish Kumar Mitu Sharma Yixin Su Sangeeta Singh J. Tanley Ramon Casanova Fang-Chi Hsu Suzanne Craft M. M. Mielke Timothy M. Hughes Gagan Deep

Aug 2026 · Alzheimer's & Dementia · Vol 22 · 0 citations · 75 references

Medicine

Abstract

Blood‐based biomarkers are essential for early detection, monitoring, and therapeutic development in Alzheimer's disease (AD) and related dementia (ADRD), but current assays lack brain cell specificity and sensitivity to low‐abundant proteins.

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