Open access
Regional astrocyte dysregulation and altered glymphatic‐related markers in Alzheimer's disease frontal cortex
Harry Alexopoulos
X. Louka
E. D. de Natale
Kelly Koutroubi
Lisa Cashmore
M. Panayotacopoulou
I. Trougakos
H. Wilson
M. Politis
Medicine
Abstract
Astrocyte dysfunction is central to Alzheimer's disease (AD), yet expression patterns of astrocytic markers remain poorly defined. We measured Aquaporin‐4 (AQP4) and glial fibrillary acidic protein (GFAP) in post‐mortem frontal cortex of AD patients and controls across BrainNet Europe (BNE) stages.