Aug 2026· Journal of Artificial Intelligence and Information· Vol 8, pp. 101-106· 0 citations· 35 references
TL;DR
This study systematically analyzes the pathophysiological significance of plasma glial fibrillary acidic protein (GFAP) in Alzheimer’s disease (AD) and systematically analyzes its expression heterogeneity and clinical interpretive boundaries.
Abstract
Based on the “vascular-inflammation axis” analytical framework, this study evaluates the pathophysiological significance of plasma glial fibrillary acidic protein (GFAP) in Alzheimer’s disease (AD). We systematically analyze its expression heterogeneity and clinical interpretive boundaries, specifically comparing late-onset AD (LOAD) and early-onset AD (EOAD).
There is a need for early, objective markers of Alzheimer's disease (AD)‐related synapse dysfunction in adults with Down syndrome (DS). The presynaptic protein β‐synuclein is elevated in the blood of adults with DS. This study evaluates the positioning of these changes relative to changes in pathophysiological blood bi...
Alba Cervantes González, A. Morcillo-Nieto, Sara Serrano et al.· Alzheimer's & Dementia· 0 citations
Co‐pathologies – including Lewy body, vascular, and TDP‐43 lesions – are common in Alzheimer's disease (AD), contributing to its clinical and pathological heterogeneity. Genetic risk factors may drive mixed pathology presentation, but their influence on the development of specific co‐pathologies remains unclear.
Madison M. Reeves, Anna Calliari, Tiffany W. Todd et al.· Alzheimer's & Dementia· 0 citations
Parkinson’s disease is increasingly recognized as a heterogeneous syndrome characterized by diverse pathological processes and clinical manifestations. Here, we propose a multidimensional framework to assess this heterogeneity, with each dimension potentially captured using advanced magnetic resonance imaging technique...
M. Pokotylo, N. Bruggemann, Jannik Prasuhn· npj Parkinson's Disease· 0 citations
Traditional dementia research often isolates single aspects, biomarkers or symptoms, overlooking complex interactions shaping disease risk and progression. Lysosomal and mitochondrial dysfunction, reflecting systemic processes, may explain links between Alzheimer’s and metabolic, inflammatory, cardiovascular, ageing, g...
P. Barnaghi, Antigone Fogel, C. Walsh et al.· Communications Medicine· 0 citations
The results suggest that APOE4 increases cholesterol levels and impairs lysosomal function in astrocytes, which release pathogenic α-Syn inclusions in APOE4 carriers.
Nicole R. West, Julia Tcw· Cell Stem Cell· 0 citations
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