miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models

Inhibition of Moesin and CD44 in stem cell‐derived neurons affects the pathological genetic signature associated with Alzheimer's disease

Using human induced pluripotent stem cells (hiPSCs)‐derived neurons, human induced pluripotent stem cells were assayed how reducing gene expression of MSN and CD44 affected amyloid beta secretion, tau phosphorylation, and transcriptional state.

Unique transcriptomic alterations in 5XFAD;PS19 mouse model identify glial lipid dysregulation and coordinated microglial–oligodendrocyte responses

Alzheimer's disease (AD) features amyloid beta (Aβ) plaques and tau tangles, yet how their coexistence reshapes brain transcriptomic programs remains unclear.

Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

This data indicates that suppression of dopaminergic neurons in the substantia nigra results in striatal dopamine depletion and motor dysfunction in Parkinson's disease, and further studies are needed to establish a specific mechanism behind this phenomenon.

Disruption of hippocampal upstream regulators of mTOR and insulin pathways in Down syndrome with Alzheimer's disease neuropathology: Preliminary observations

It is hypothesized that upstream alterations in these two pathways contribute to hippocampal dysfunction in DS‐AD.

Parkinson's gene linked to early dysfunction in brain cells

Epigenetic control of hippocampal stem cells: modulation by hyperactivation, glucocorticoids and aging