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Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

B. Qin Zichu Fu Xuanxuan Zou Senmao Chai Jingjing Weng Puqing Wang Xiaodong Sun Ming Sang
Jul 2026 · Animal Models and Experimental Medicine · Vol 9, pp. 1613 - 1632 · 0 citations · 46 references
Medicine

TL;DR

This data indicates that suppression of dopaminergic neurons in the substantia nigra results in striatal dopamine depletion and motor dysfunction in Parkinson's disease, and further studies are needed to establish a specific mechanism behind this phenomenon.

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive degeneration of midbrain substantia nigra dopaminergic neurons, resulting in striatal dopamine depletion and motor dysfunction. While this pathological cascade is well‐established, its underlying mechanisms remain elusive.

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