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A Subset of FOXO1‐Fusion Negative Rhabdomyosarcoma With Round Cell (Alveolar) and “Burkitt‐Like” Morphology Is Associated With High Amplification of MYCL: A Report From the Children's Oncology Group

Sonja D. Chen Wei Xue Cora A. Ricker Julia Schiantarelli Natalie B. Collins E. Rudzinski Archana Shenoy Lisa A. Teot Abha A. Gupta S. Wolden R. Dasgupta R. Venkatramani Kelly S. Klega M. Arnold B. Crompton

Oct 2026 · Genes, Chromosomes and Cancer · Vol 65 · 0 citations · 23 references

Medicine

Abstract

Alveolar rhabdomyosarcoma (ARMS) is a distinct histologic subtype of rhabdomyosarcoma, associated with the presence of a PAX3 or PAX7::FOXO1 gene fusion in approximately 80% of cases. Adverse outcomes for patients with ARMS are associated with the presence of a FOXO1 gene fusion; however, additional genetic markers are necessary to better characterize FOXO1‐fusion negative ARMS.

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