The case of a 65-year-old man with a history of recent travel to a tropical country who was found to have multiple hepatic abscesses is presented and the clinical and microbiological picture was most consistent with amoebic liver abscess secondary to E. histolytica; however, the presence of Blastocystis species introduces uncertainty around its clinical significance.
Abstract
Abstract Blastocystis hominis is a ubiquitous intestinal parasite commonly detected in human stools. Queries about the pathogenic nature of B. hominis in immunocompetent individuals have been raised with conflicting reports about the clinical significance of detecting the parasites in various specimens. Reports have documented invasive intestinal infections and the detection of Blastocystis species in both a splenic cyst and a hepatic abscess. We present the case of a 65-year-old man with a history of recent travel to a tropical country who was found to have multiple hepatic abscesses. Analysis of the hepatic abscess fluid confirmed the presence of Entamoeba histolytica and Blastocystis species, and, to our knowledge, this is the second reported case of the same findings. Overall, the clinical and microbiological picture was most consistent with amoebic liver abscess secondary to E. histolytica; however, the presence of Blastocystis species introduces uncertainty around its clinical significance. Further studies are required to investigate the pathogenicity of Blastocystis species, including molecular investigations into the various genetic subtypes.
A 31-year-old liver transplant recipient who developed progressive diffuse papulopustular and verrucous necrotic cutaneous lesions 17 months after transplantation is reported, highlighting the diagnostic complexity of invasive fungal infections in non-endemic regions and the importance of early molecular identification in immunocompromised patients presenting with atypical cutaneous and systemic fungal disease.
F. Ghiasvand, Safoura Shakoeinejad, Negar Hemmati et al.· Mycopathologia· 0 citations
The case of a 48-year-old patient recently diagnosed with HIV and a CD4 lymphocyte count of less than 50 cells/ uL, who consulted for prolonged fever without apparent focus, highlights the importance of considering nocardiosis in the differential diagnosis of prolonged fever with multiple deep lesions in immunocompromised patients.
María Trinidad Pennini Guelfi, Camilo Martínez, Ana De Lajonquiere et al.· Medicina· 0 citations
This review highlights the significance of a multidisciplinary approach, increased awareness among high-risk groups, and continued epidemiological monitoring for future outbreaks of mucormycosis.
BACKGROUND
Non-tuberculous mycobacteria (NTM) are important opportunistic pathogens that most commonly infect the lungs. Primary involvement of the gastrointestinal tract-especially the small intestine-is exceedingly rare, and small-bowel infection caused by Mycobacterium kansasii (M. kansasii) has seldom been reported.
CASE PRESENTATION
We describe an extremely rare case of primary small-intestinal M. kansasii infection in an immunocompetent young man who presented with prolonged chronic diarrhea and fever. After an extensive but unrevealing diagnostic work-up, the etiology was finally established by microbial metagenomic sequencing of tissue obtained by double-balloon endoscopy. Building on the initial regimen of ethambutol hydrochloride, rifampicin, and clarithromycin-and with subsequent antibiotic adjustments tailored to the patient's evolving symptoms-clinical symptoms resolved completely, and follow-up endoscopy showed mucosal improvement.
CONCLUSION
This case underscores that NTM infection should be considered in the differential diagnosis of unexplained chronic gastrointestinal symptoms and highlights the pivotal role of modern molecular techniques in reaching a precise diagnosis. Detailed analysis of the case together with a review of the literature aims to raise clinicians' awareness and improve management of this rare entity.
Lan Wu, Jiayao Wang, Jin Zhu et al.· BMC Infectious Diseases· 0 citations
Pyogenic liver abscess (PLA) has traditionally been considered prevalent in Asia. However, its incidence is increasing in Europe.
Klebsiella pneumoniae
(Kp) has emerged as the leading causative pathogen, and hypervirulent strains pose a higher risk of invasive disease and metastatic complications, such as endogenous endophthalmitis (EE).
The case describes a 77-year-old woman who presented with fever and right upper quadrant abdominal pain. She was diagnosed with a second episode of PLA within 3 months, caused by Kp. Despite prompt antimicrobial therapy and percutaneous transhepatic drainage, the patient developed acute vision loss in the left eye during hospitalization. Ophthalmologic assessment confirmed EE secondary to bacteremia. Whole-genome sequencing identified the isolate as hypervirulent Kp (hvKp) sequence type 23 (ST23). While the liver abscess resolved following treatment, the patient sustained permanent loss of vision in the affected eye despite aggressive medical and surgical management.
This case illustrates the invasive nature of hvKp and its potential for recurrence and metastatic complications. Improved recognition through targeted virulence testing is essential to avoid underdiagnosis.
This case highlights the aggressive nature of hvKp. Early recognition of systemic and ocular symptoms, prompt ophthalmologic evaluation, and timely source control are essential. Optimal management requires multidisciplinary collaboration and the use of molecular diagnostics, including whole-genome sequencing, to identify hypervirulent lineages and support surveillance.
Laura Veinberga, Anna Elizabete Liepina, I. Markevica et al.· International journal of sur...· 0 citations
A clinical case of cutaneous cryptococcosis in a domestic cat, presenting a single lesion on the abdominal wall, without ulceration, an uncommon presentation in veterinary literature is reported on.
R. R. Latorre, M. C. C. Pellissari, C. T. Gaggini et al.· Arquivo Brasileiro de Medici...· 0 citations