TL;DR
The research revealed that the AA genotype of p.Ala946Thr polymorphism was associated to protection against COVID-19 infection, and identified several novel rare variants in IFIH1 that displayed a cumulative protective effect against susceptibility to severe COVID-19.
INTRODUCTION Following the COVID-19 pandemic, increasing attention has been directed toward host genetic factors that influence disease severity. The interferon-induced transmembrane protein 3 (IFITM3) plays a key role in restricting viral entry, and its rs12252 polymorphism has been linked to impaired antiviral defens...
The global allele frequency data show that CCR5Δ32 is controversially associated with several diseases, including COVID-19, and the first report of this allele’s frequency in Iraqi Kurds is a unique and novel contribution to population genetics.
BACKGROUND DECTIN-1, a C-type lectin receptor encoded by CLEC7A, mediates antifungal immunity, but its antibacterial role remains unclear. We investigated, using human genetic and animal studies, whether the common loss-of-function CLEC7A Y238∗ variant (rs16910526) influences susceptibility to bacterial respiratory inf...
It is suggested that ACE2 genetic variability is associated with modulation of inflammatory responses and may contribute to organ-specific dysfunction in COVID-19 and TB across different populations.
TYK2 and NOTCH4 variants are markedly associated with increased COVID-19 severity and mortality, indicating their potential as genetic biomarkers for risk stratification and support the importance of host genetics in disease progression.
Individuals infected with Coronavirus Disease 2019 (COVID-19) may exhibit a wide range of clinical symptoms, from asymptomatic cases to severe complications. This variation is likely associated with differences in immune response intensity, where specific long noncoding RNAs (lncRNAs) are known to regulate the interfer...
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