The authors' bioinformatic analyses expand the repertoire of auxiliary metabolic genes in Phycodnaviridae by identifying a conserved heme degradation pathway, non-canonical vHMOX1/PcyA targeting and structural rearrangements surrounding the catalytic sites of viral HMOX1.
Structural features suggest that the Methylomonas protein that is identified may act as a BLF1-like deamidase but against a currently unknown target, and that other bacterial proteins with similar sequence fingerprints could play important roles in broader bacterial biology.
Nur Afiqah Shalihin Muhamad Ismail, Amirul Adli Abd Aziz, Atsushi Nakagawa et al.· Acta Crystallographica Secti...· 0 citations
This study proposes a working model for SAP55-mediated host manipulation, and establishes a foundation for future experimental investigation, as well as providing a comprehensive computational framework for a candidate membrane-associated candidate effector.
Kayhan Derecik, G. Oz, Işıl Tulum· Scientific Reports· 0 citations
A systematic computational workflow is presented for the identification and structural analysis of putative effector proteins in Ustilago maydis, a biotrophic model fungus, providing a framework to prioritize effector candidates for experimental validation and can be readily applied to diverse fungal pathogens.
Max Heinen, Florian Altegoer· Methods in molecular biology· 0 citations
The Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism (MAPEG) superfamily comprises integral membrane proteins involved in lipid metabolism, detoxification, and redox regulation. While extensively characterised in eukaryotes, bacterial MAPEG homologs remain poorly understood. In this study, we condu...
L. Federici, M. Masulli, V. De Laurenzi et al.· Current Issues in Molecular...· 0 citations
IME1s are proposed, a novel group of viruses associated with Dehalococcoidia that have double stranded DNA (dsDNA) genomes and a non-lytic, likely filamentous lifestyle and expand the known diversity of bacterial viruses.
C. Nesbø, Nadia Morson, O. Molenda et al.· bioRxiv· 0 citations
Successive genome improvements reveal that while AP5292 and AP143 remain conserved, AP1260 and especially AP10948 have expanded into highly divergent multi-haplotype families, with AP10948 now comprising 25 tandemly duplicated variants.
J. V. Sullivan, M. Currie, P. J. Prendergast et al.· Australasian Plant Pathology· 0 citations
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