Anticancer activity of lichen-derived compounds against triple-negative breast cancer: integrated in vitro evaluation, network pharmacology, molecular docking, and KEGG pathway analysis.
The results of the present study suggest that ML can inhibit the proliferation and migration of BRCA cells whilst inducing their apoptosis by regulating the expression of key proteins.
Jun Zhang, Guo-Xin Zhao, Renping Zhang et al.· American Journal of Cancer R...· 0 citations
It is suggested that kirenol, artesunate, apigenin, daidzein, and sclareol have the potential to target specific genes involved in chemoresistance in TNBC and can serve as therapeutic options against drug-resistant TNBC.
R. Raj, S. Dang, R. Gabrani· Medicinal Plants - Internati...· 0 citations
Tryptophenolide (Lei4) showed moderate but reproducible anti-CRC activity and directly inhibited EGFR kinase activity in vitro, supporting EGFR pathway inhibition as one mechanism contributing to its cellular effects.
Qian Gu, Shi-Lei Zhao, Xin Zhang et al.· Journal of Computer-Aided Mo...· 0 citations
Background: Triple-negative breast cancer (TNBC) represents an aggressive subtype that has few therapeutic options for targeting and is highly resistant to chemotherapy. The compound RRx-001 is a dinitroazetidine compound with both immune-modulating and epigenetic properties, whereas oxaliplatin elicits immunogenic cel...
R. K. Al-Fatlawi, W. Al-khfajy· Al-Rafidain Journal of Medic...· 0 citations
The erucin-kaempferol combination demonstrated synergistic anticancer activity against A549 NSCLC cells, highlighting the bioactive potential of naturally co-occurring E. sativa-derived phytochemicals.
The combined computational and experimental approach enabled the identification of peptides with selective cytotoxic effects and favorable predicted immunogenic profiles, demonstrating that integrating computational screening with experimental validation is an effective strategy for accelerating the discovery of select...
Isabella Fagundes Gurgel, Ana Carolini Almeida Marcarini, Carlos Marchiorio Lacerda et al.· International Journal of Pep...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.