The findings reveal partial genetic overlap between altered brain aging and diverse psychiatric disorders, providing an integrative cross-modality perspective on the shared genetic influences and related biological pathways linking brain aging and psychiatric vulnerability.
It is found that schizophrenia and ADHD show distinct genetic patterns: schizophrenia shares more genetic factors with brain structure and diabetes, while ADHD is more strongly linked to metabolic pathways.
J. Kopal, A. Shadrin, D. van der Meer et al.· Communications Medicine· 0 citations
A high-resolution cellular and temporal framework of SZ susceptibility is established, implicating mature associative IT microcircuits, deep-layer thalamocortical-regulating networks, and early developmental specification windows as primary points of genetic convergence in SZ.
Yong Wu, Yuan Gao, Miao Li et al.· Molecular Psychiatry· 0 citations
Neurological and psychiatric disorders (NPDs) impose a substantial global burden. Many genetic associations have been reported for a range of NPDs, but the specific genes and proteins underlying susceptibility and their tissue- and cell type-specific manifestations remain poorly understood, hindering the developmen...
Yuanhao Yang, Yuan Zhou, Xin Lin et al.· BMC Psychiatry· 0 citations
The shared genetic architecture between rheumatoid arthritis and psychiatric disorders is elucidated, providing novel insights into the pathological mechanisms underlying their comorbidity and laying groundwork for improved comorbidity management.
Xin Ke, Shi Yao, Xi Zheng et al.· Rheumatology· 0 citations
The findings suggest that genetic influences on brain morphology are expressed across multiple spatial scales, with consequences that may help to guide the design of deep learning methods to discover genomic loci associated with brain structure and brain diseases.
Emma J Gleave, Luis M. García-Marín, Z. Ceja et al.· bioRxiv· 0 citations
Brain iron accumulation is well established in Alzheimer's disease (AD), but whether the two share a genetic basis remains unclear. Here, we performed genome-wide association analyses of brain iron across six iron-rich brain regions, quantified via quantitative susceptibility mapping (QSM) in 38,142 UK Biobank particip...
M. R. Rahman, Y. Xia, P. Raniga et al.· medRxiv· 0 citations
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