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Histological assessment of integrated human cortical organoid grafts after controlled cortical impact

Caitlyn J Smith S. Hamimi M. Castellanos Emma Noel Ana Paulina Serrano Said Inaltekin Nirvaa Shah Willam Perez F. Rauscher Jaeha Kim Hailong Song Victoria E. Johnson Han-Chiao I. Chen Dennis Jgamadze
Jul 2026 · bioRxiv · 0 citations · 50 references
Biology Medicine

TL;DR

The results support the feasibility of using human organoid grafts in rats as a model of TBI, potentially including the study of long-term neurodegeneration and microbial penetration of the brain after injury.

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