Aug 2026· Clinical and Translational Oncology· 0 citations· 72 references
Medicine
TL;DR
This review synthesizes current data on cellular, molecular, and systemic predictors, focusing on immune cell phenotypes, protein biomarkers, gene signatures, and metabolic factors, focusing on immune cell phenotypes, protein biomarkers, gene signatures, and metabolic factors.
A novel AIGScore model with significant prognostic utility for PDAC is proposed, which may provide insights into TME characteristics and offer a potential framework for optimizing immunotherapeutic strategies in patients with PDAC.
Qing Chang, Qian Wang, Xiumei Jiang et al.· Visual Information Expert Wo...· 0 citations
This review addresses the limitations of currently used biomarkers across lung cancer histologies and describes emerging immune-related biomarkers encompassing innate immune infiltration, antigen presentation capacity, cytotoxic T-cell activation, and inflammatory signaling that have shown promise as histology-independ...
E. Gobbini, Subhamoy Chakraborty, I. Vathiotis et al.· Cancer immunology research· 0 citations
New insights from single-cell and spatial profiling technologies support a more integrated model of FL biology and provide a foundation for developing microenvironment-directed therapies and precision medicine approaches.
Zhi-Zhang Yang, Stephen Ansell· Expert Review of Clinical Im...· 0 citations
This review summarizes the most promising biomarkers currently being investigated in metastatic colorectal cancer, including those measured in tumor tissue and those detected through blood-based tests, as well as emerging metabolic and lipid-related signatures.
E. Benidovskaya, N. Huyghe, M. V. Giolito et al.· Cancers· 0 citations
Focusing on acquired resistance as a core bottleneck in precision therapy, mechanisms underlying anti-Human Epidermal Growth Factor Receptor 2 (HER2) resistance and primary/secondary resistance to immune checkpoint inhibitors (ICIs) were systematically dissected, while also addressing immune-related adverse events and...
This narrative educational review aims to provide a comprehensive overview of recent advances in the understanding of ovarian cancer pathogenesis, the molecular mechanisms driving tumor progression, and the multifaceted role of the immune system in disease development and therapeutic response.
B. Vavrušáková, R. Bartošová, M. Hendrych et al.· Discover Oncology· 0 citations
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