2026· International review of neurobiology· Vol 188, pp.
199-229
· 0 citations
Medicine
TL;DR
This chapter summarizes current knowledge of the microbiota-gut-brain axis (MGBA) and elucidates how intestinal microbes and their metabolites communicate with the central nervous system via neural, immune, endocrine, and metabolic pathways.
The gut microbiota acts as an upstream regulator of AD pathology through interconnected molecular mechanisms, and microbiota-targeted interventions have the potential to modulate these pathways and improve cognitive outcomes, although results vary across studies.
Javeria Fatima, Y. Siddique· CNS and Neurological Disorde...· 0 citations
This review synthesizes recent advances in understanding how peripheral immunity and gut microbiota influence neurodegenerative processes, highlighting key signaling pathways and mechanisms and examines current therapeutic strategies.
Vishwadeep Singh, V. Saxena, Sanskriti Upadhyay· Journal of Human Nutrition a...· 0 citations
Overall, current evidence suggests that gut microbial dysbiosis is closely associated with neuroinflammation and autonomic dysfunction in neurodegenerative diseases and may represent a promising avenue for biomarker discovery and therapeutic intervention.
Background & Objective: The gut-brain axis is essentially a two-way communication system that physically connects the brain and the intestinal tract. The connection is mediated through a series of pathways, including neural, endocrine, and immune pathways. Gut dysbiosis, which is explained as an imbalance in the microb...
M. Azimzadeh, Shima Ababzadeh, Ali Ganji Kahaki et al.· Iranian Journal of Pathology· 1 citation
This review examines the current evidence linking gut microbiota imbalance to dementia through mechanisms involving immune regulation, metabolic signalling, and neuronal stability through mechanisms involving immune regulation, metabolic signalling, and neuronal stability.
Jayesh S. Bhamare, P. Jha, Meena Chintamaneni et al.· Ageing Research Reviews· 0 citations
A better understanding of the GM-miRNA axis may facilitate the development of novel biomarkers and personalized therapeutic strategies, ultimately shifting MS management from symptomatic treatment toward precision, disease-modifying interventions.
Farzaneh Rafie Sedaghat, A. Hasani, V. Poortahmasebi et al.· Folia Microbiologica (Prague...· 0 citations
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