In silico Computational Study of Cinnamon ( Cinnamomum verum ) Bioactive Compounds as Cancer-Immunotherapy Drug Candidate Targeting RAS-JAK-ERK Signaling Pathway to Inhibit the Programmed Death Protein Ligand 1 (PD-L1) Expression

W. E. Putra Sustiprijatno A. Hidayatullah Diana Widiastuti M. F. Heikal Wira Eka

· 0 citations

TL;DR

The active compound of cinnamon was effective and had the potential to inhibit the JAK protein, but not RAS or ERK, and according to the biological activity predictions, cinnamon bioactive compounds contribute as cancer fighting agents by having high Pa values for several parameters.

Semantic Scholar

View source

Similar papers

Aug 2026

Flavonoid-Enriched Extract of Carissa carandas Linn Triggers Apoptosis and Cell Cycle Arrest in A549 Lung Cancer Cells: An Integrated In-Vitro and In-silico Approach Targeting CDK2 and Bcl-2

The findings suggest that EECC exerts anticancer effects against A549 lung carcinoma cells primarily through ROS-mediated apoptosis and cell cycle arrest.

Priyanka Bajpai, Phool Chandra, Om Prakash · The Natural Products Journal · 0 citations

Open access Sep 2026

Integrative Network Pharmacology and Experimental Validation of Sesbania grandiflora as a Multi-Targeted Therapeutic Agent Against Oral Squamous Cell Carcinoma (OSCC).

BACKGROUND Oral squamous cell carcinoma (OSCC) remains a significant health burden with limited therapeutic options and high mortality. Sesbania grandiflora, a medicinal plant rich in phytochemicals, has been traditionally used for its medicinal properties and is emerging as a potential anticancer agent. OBJECTIVE Th...

Reyana Begam R, Gheena Sukumaran, Abilasha Ramasubramaniam · Asian Pacific Journal of Can... · 0 citations

Review Open access Aug 2026

Cinnamaldehyde From Cinnamon as a Food‐Derived Bioactive: Phytochemistry, Anticancer Mechanisms, Bioavailability, Nanoformulation and Safety

Cinnamaldehyde (CA), a bioactive compound derived from Cinnamomum species, has gained attention for its potential anticancer properties. Preclinical evidence suggests that CA exerts antitumor effects through multiple mechanisms, including the induction of apoptosis, modulation of redox homeostasis, inhibition of...

Gervason Moriasi, S. Kamau, G. Seitimova et al. · Food Frontiers · 0 citations

Open access Sep 2026

Elucidating the multitarget therapeutic potential of Camellia sinensis (Tea) phytochemicals using network pharmacology, functional annotation, and molecular docking

Findings provide mechanistic insights into the multi-target pharmacological potential of C. sinensis phytochemicals and highlight their prospective therapeutic relevance against cancer, metabolic, inflammatory, and neurodegenerative disorders.

Md. Mainuddin Hossain · Discover Chemistry · 0 citations

Aug 2026

Anticancer activity of lichen-derived compounds against triple-negative breast cancer: integrated in vitro evaluation, network pharmacology, molecular docking, and KEGG pathway analysis.

Lichen-derived compounds atranorin, barbatic acid, and usnic acid demonstrated anticancer activity in vitro, while integrated computational analyses suggested potential multitarget interactions that warrant further experimental validation.

Sachin V. Mapari, S. Gaikwad, Ruchira R. Sutar et al. · Naunyn-Schmiedeberg's Archiv... · 0 citations

Open access Aug 2026

In Silico Study of Bioactive Compounds from Moringa oleifera Extract as Anti-Inflammatory Candidates Targeting the Inflammatory Mediator PGD2

This in silico study evaluated 12 bioactive compounds from an ethanolic extract of M. oleifera as potential inhibitors of this molecular target and identified quercetin, apigetrin, chlorogenic acid, ellagic acid, and naringenin as the most promising candidates.

Putri Sabilla, T. Sari · Journal multidisciplinary sc... · 0 citations