TL;DR
It is suggested that ginsenoside Rh1 may mitigate allergic reactions through a multi-target and multi-pathway network, providing a theoretical basis for its development as a promising anti-allergic agent.
CNZP exhibits significant therapeutic effects on RA, potentially by downregulating NOS1 expression and subsequently correcting the metabolic imbalance of L-arginine, and this preclinical study provides mechanistic evidence for the anti-RA effect of CNZP.
BACKGROUND Rosacea is a chronic inflammatory skin disorder with limited therapeutic options. Puhuaiyin (PHY), a traditional Chinese medicinal formula, shows clinical efficacy, but its multi-component mechanisms remain unclear. METHODS Chemical constituents of PHY were identified by UPLC-Q-TOF-MS. Network pharmacology...
The findings suggest that N. sativa may provide dual therapeutic benefits by modulating host immune responses and targeting pathogen proteins, supporting its potential for future anti-sepsis drug development based on computational predictions that require experimental validation.
Findings provide mechanistic insights into the multi-target pharmacological potential of C. sinensis phytochemicals and highlight their prospective therapeutic relevance against cancer, metabolic, inflammatory, and neurodegenerative disorders.
It is suggested that Isatis indigotica acts on HBV-associated hepatic inflammation through multi-target synergistic regulation of NF-κB and JAK-STAT signaling pathways, providing mechanistic insights and potential therapeutic targets for HBV management.
Results indicate that GQYS treats DN mainly through the anti-inflammatory effects, providing a potential theoretical basis for its clinical application and demonstrating the reliability of the integrative strategy.
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