Aug 2026· Current Behavioral Neuroscience Reports· Vol 13· 0 citations· 131 references
TL;DR
The neurobiological basis of cognitive impairment in MDD is explored, key biomarkers associated with these deficits are identified, and their implications for diagnosis, prognosis, and therapeutic intervention are discussed.
A framework is provided for understanding the neural substrates of somatic symptoms in MDD, developing somatic phenotype-based biomarkers and targeted neuromodulation therapies, and integrating systems-level neuroimaging into precision psychiatry to advance biologically informed diagnosis/treatment.
The moderating effect of CR on the brain network-cognition association provides a neurobiological rationale for this vulnerability and supports incorporating CR into routine clinical assessment to guide risk stratification and personalized treatment planning.
M. Gruber, Henrike Renaud, M. Mauritz et al.· Psychotherapy and Psychosoma...· 0 citations
Abstract Background Mood disorders are major contributors to the global burden of disease. There is a critical need for reliable markers that can identify individuals at elevated risk for developing mood disorders and predict poor prognosis among those already affected, in order to guide personalized interventions. Aim...
A. Sankar, B. Ozenne, V. Dam et al.· International Journal of Neu...· 0 citations
An Integrated Exercise–Neurobiology Model linking exercise prescription with coordinated physiological and neurobiological adaptations that may guide future mechanistic research and precision exercise interventions is proposed.
Adam Tomczak, P. Ziajka, Agnieszka Zwolińska et al.· Quality in Sport· 0 citations
Introduction and objective: Major depressive disorder (MDD) is a heterogeneous psychiatric condition characterized by affective, cognitive and somatic symptoms that considerably impair daily functioning. It is defined clinically by prolonged low mood, diminished interest or pleasure, and a range of associated disturban...
Maciej Kisielewski, Natalia Fidut, Jakub Skrzypek et al.· Quality in Sport· 0 citations
Baseline cortical morphometric features were associated with clinical and cognitive changes following antidepressant treatment in MDD, and single-ROI LOOCV models based on left cuneus and left SFC FD showed cross-validated associations with symptom improvement.