A role for Spag6 is demonstrated in the pathogenesis of OM in mice, possibly through its role in the regulation of cilia/basal body polarity through the PCP-dependent mechanisms in the middle ear and Eustachian tubes.
Investigating how primary cilia, structures that detect and transmit signals, form contacts with one another in a head sensory organ of the nematode Caenorhabditis elegans found that these contacts follow consistent patterns and can form even when neighboring cilia are absent, suggesting they are actively established r...
A distinct population of ependymal cells (E2) in the forebrain of mice and humans are described, identified as a novel CSF-sensing ependymal cell type and provide a cellular target for the CSF signaling.
A. Cebrian-Silla, Fiona Dale-Huang, Stephanie A. Redmond et al.· bioRxiv· 0 citations
It is demonstrated that central nervous system-specific inactivation of Tmem216 results in severe postnatal hydrocephalus and is identified as a critical TZ protein essential for ciliogenesis during ependymal development and establishing ependymal planar cell polarity.
Qian-Qian Gong, Zhuo-Wen Lv, Zhi-Lin Dou et al.· Proceedings of the National...· 0 citations
These findings uncover an active, centrosome-dependent, cell-autonomous mechanism for maintaining and repairing mature metazoan cilia in fully grown organs in adulthood and also provide a possible explanation for how deregulation of conserved ciliary base components could lead to progressive, late-onset cilia-related d...
Minita Desai, P. Priya, Shriya et al.· bioRxiv· 0 citations
The structural and functional organization of the ependymal cilia is described and how ciliary defects range from severe developmental disruptions causing neonatal hydrocephalus to subtle maintenance defects underlying late-onset forms of the disease are discussed.
Shinya Ohata, Maki Takagishi· Biological and Pharmaceutica...· 0 citations
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