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ABTB1, as an E3 ubiquitin ligase, suppresses Th17 cell differentiation and mitigates autoimmune inflammation by promoting STAT3 ubiquitination and degradation

Fei Xu Shuang Zhao Yan Jiang Xiao-Ping Li Wen-Jun Wang Ying Zhou Yu-Feng Wang Pei-Jie Zhu Yuan-Yuan Shao Guo-Dong Qiao Jia-Min Cai Meng-Yao Sun Jiao-Yang Li Chuang-Li Hao Yi Yang Jin-Ping Zhang
Aug 2026 · Cellular & Molecular Immunology · Vol 23, pp. 1285 - 1307 · 0 citations · 103 references
Medicine

TL;DR

The research demonstrates the critical role of ABTB1 in regulating the differentiation and function of Th17 cells under conditions of autoimmune diseases and may represent a potential therapeutic target for inflammatory bowel disease (IBD) and other autoimmune disorders.

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