Probiotic-Derived Antimicrobial Proteins and Peptides: Molecular Mechanisms, Clinical Applications, and Future Therapeutic Perspectives.

Review Open access Aug 2026

Bacteriocin-Producing Probiotics as Precision Antimicrobial Therapeutics: From Lactic Acid Bacteria to Emerging and Engineered Next-Generation Platforms

Overall, LAB-derived bacteriocins have the most substantial evidence for production, characterization, and safety, while NGP-associated systems are promising but mostly preclinical and need further structural and functional validation.

Vishakha Tyagi, Ajay Kumar, N. Thapliyal et al. · Applied microbiology · 0 citations

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Review Aug 2026

Antimicrobial peptides and enzymes: synergistic mechanisms and strategies for disrupting biofilm-associated infections.

This review collates the existing literature on zoonotic and bacterial origin AMPs, along with the matrix-disrupting and quorum-quenching enzymes, highlighting those which have proven to be effective in vitro/in vivo against clinical isolates from patients and identifies specific physiological and challenges that need...

S. Shukla, B. D. Iyer · Critical reviews in microbio... · 0 citations

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Review Open access Sep 2026

Reframing Antimicrobial Peptides beyond Direct Antimicrobial Activity toward Host-Directed Functions and Disease-Specific Therapeutic Applications

Antimicrobial peptides (AMPs) have been extensively investigated as alternatives to conventional antibiotics to combat multidrug-resistant bacteria. This narrow antibiotic-replacement framework underestimates the biological and translational potential of AMPs. The present review reframes them as disease-context-depende...

Min-Ho Lee · Journal of Microbiology and... · 0 citations

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Review Sep 2026

PLANT-DERIVED THERAPEUTICS AS A NOVEL STRATEGY TO COMBAT ANTIMICROBIAL RESISTANCE: CURRENT ADVANCES AND FUTURE PERSPECTIVE

Overall, plant-derived therapeutics represent a promising and sustainable avenue for the discovery and development of complementary antimicrobial strategies to address the growing global burden of AMR.

Deeksha Rathor, Pushpendra Kumar, Km. Neha et al. · GLOBAL JOURNAL OF PHARMACEUT... · 0 citations

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Review Open access Sep 2026

Alternative Approaches to Antibiotics: Phage Therapy, Antimicrobial Peptides, and Phytotherapeutics

Antibiotic resistance has emerged as a critical threat to global health, food security, and economic stability due to the overuse of antibiotics in human medicine and livestock production. This review examines the mechanisms of antibiotic action and resistance, clinical and environmental consequences of resistance, and...

Haruna Abdullahi, Haliru Ahmad Kabiru, Habila Mamman Paul et al. · FUDMA Journal of Sciences · 0 citations

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Review Open access Aug 2026

Defensins as natural antimicrobial peptide scaffolds against antimicrobial-resistant pathogens: mechanisms, resistance risks, and translational prospects

Existing evidence does not support classifying defensins as resistance-proof or uniformly less resistance-prone than conventional antibiotics, so they should be regarded as versatile scaffolds whose resistance risk requires candidate-specific evaluation.

E. Abdallah, S. Al-Mijalli, N. al Hakawati et al. · Frontiers in Cellular and In... · 0 citations

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