Skip to content
Log in
Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

STAT6 Targets the Autophagy Pathway to Regulate Microglial Senescence in Cognitive Impairment Caused by Cerebral Small-Vessel Disease

Xiaolu Liu Qing Liu Jingwen Yang Xia Hu Xiaoqiu Zhu Zhan Zhang You Zuo Jialin Huang Lele Wu Yu-Hua Fan Yamei Tang Zhongshan Shi
Jul 2026 · Neuromolecular medicine · Vol 28 · 0 citations · 58 references
Medicine

TL;DR

Mechanistically, it was found that phosphorylated STAT6 (pSTAT6) enhanced autophagy, which reduced the burden of senescent microglia and thereby ameliorated CSVD-induced VCI, providing insights into the potential of targeting the STAT6 pathway in VCI associated with CSVD.

DOI PubMed Semantic Scholar
View source

Similar papers

Open access Aug 2026

Targeting Microglial HDAC3 Enhances Aβ Clearance and Neuroprotection in APP/PS1 Mice: A Ketogenic Diet‐Driven Strategy

It is reported that a 12‐week ketogenic diet treatment ameliorated cognitive deficits, reduced amyloid‐β (Aβ) deposition and tau hyperphosphorylation, and attenuated neuroinflammation in male APP/PS1 mice, suggesting a novel mechanism by which KD exerts neuroprotective effects through modulation of the microglial HDAC3...

Mingxiao Zheng, Gabriele Loers, Sheng-Nan Lin et al. · 0 citations
Review Aug 2026

[Immune Checkpoint Tim-3 Regulates Microglial Function in Alzheimer's Disease].

It is suggested that Tim-3 acts as a functional checkpoint that limits beneficial microglial responses in AD and that targeting Tim-3 may therefore represent a promising therapeutic strategy for reprogramming microglia and improving disease outcomes.

Kimitoshi Kimura · 0 citations
Review Aug 2026

Mechanisms and therapeutic potential of microglia-regulated remyelination in chronic cerebral hypoperfusion.

The molecular and cellular mechanisms underlying white matter injury after chronic cerebral ischemia are summarized, with particular emphasis on the dynamic regulation of microglia and their interactions with other cell types.

Zhe-Rui Yang, Xiaoli Qin, Yun-Sha Zhang et al. · 0 citations
Open access Aug 2026

Reduced microvascular coverage links a hypoxia-associated niche to microglial autophagic dysfunction in Parkinson’s disease

A “double-hit” model in which hypoxia-associated stress may amplify α-Syn-induced microglial dysfunction through HIF1A-linked metabolic remodeling and impaired autophagy-related protein handling is supported, which supports a “double-hit” model for advanced PD.

Hua-Lin Wang, Zhuang Zhu, Zefu Yin et al. · 0 citations
Review Open access Sep 2026

Neuroinflammation and vascular pathology in Alzheimer's Disease: The NRF2/HO-1 axis as a modulator of microglial phenotypes.

It is argued that perivascular microglia represent a key "decision hub" at the neurovascular interface, where shifts from homeostatic surveillance toward disease-associated microglia (DAM) programs influence both amyloid handling and the amplification of neuroinflammation.

M. Olazabal-Chias, M. Kratochvil, A. I. Rojo · 0 citations
Open access Aug 2026

Astragaloside IV attenuates hypoxia-reoxygenation-induced endothelial senescence and vascular inflammation by modulating the NOTCH1/VCAM-1 axis

The data suggest that AS-IV does not merely inhibit Notch1 but acts by modulating its signaling toward a protective equilibrium, thereby attenuating endothelial senescence and inflammation associated with the restoration of Notch1/VCAM-1 signaling balance.

De-Hui Huang, Rong-Jing Zhou, J. Ling · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.