It is shown that AD model mice expressing a mitophagy reporter (APP/PSEN1/mt-Keima) develop large accumulation of acidic and neutral mitochondria within neuronal processes that form a previously unrecognized pathological structure termed mitochondrial plaques (MPs).
Key features of mitochondrial homeostasis in neurons are outlined, neuropathological and clinical data supporting the relevance of TDP-43 in AD are reviewed, and emerging mechanisms by which TDP-43 may perturb mitochondrial homeostasis are synthesized.
Wendi Huang, Juan Huang, Nan-Yu Kuang et al.· Ageing Research Reviews· 3 citations
Cerebral bioenergetic metabolic failure as a central driver of cognitive decline, arising from irreversible reactive gliosis and neuroblastosis mechanisms is emphasised and various therapeutic options are highlighted, including restoration of ANLS to mitigate the pathogenesis and memory loss in AD.
Gowsika Baskar, Mahesh Kandasamy· International review of neur...· 2 citations
This chapter looks at the nature of the tau-mitochondrial interface, and proposes a paradigm of tau-induced energy failure in AD, and discusses novel therapeutic approaches that target both tau and mitochondrial abnormalities, namely antisense oligonucleotides (ASO), mitochondria targeted compounds and mitophagy modifi...
Abhay Kumar Singh, Supraja M. R., Amal P. S. et al.· International review of neur...· 0 citations
Dysregulation of ALP-associated processes, including autophagic flux, chaperone-mediated autophagy, endolysosomal trafficking, lysosomal pH and ion balance, and lysosomal metabolic signaling, is implicated in both the pathogenesis and progression of neurodegenerative diseases, with an emphasis on Alzheimer’s disease an...
Samantha R. McDonough, Aditya K. Rao, Jacqueline M. McAleer et al.· Molecular Neurodegeneration...· 0 citations
This study provides mechanistic insight into early mitochondrial dysfunction in AD and identifies the Aβ‐Me3 axis, which functions not only as a metabolic responder to Aβ‐associated stress but also as a contributor to early mitochondrial pathology.
Wen-Jie Zhu, Yuan-Yuan Zhang, Peng-Jie Li et al.· MedComm· 0 citations
The roles of mitochondrial calcium uniporter (MCU) complex and mitochondrial sodium – calcium – lithium exchanger (NCLX) in regulating mitochondrial Ca²⁺ along with the therapeutic effects of regulating mitochondrial Ca²⁺ in the brain are highlighted.
Sahishnu Saha· American Journal of Student...· 0 citations
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