Aug 2026· Apoptosis· Vol 31· 0 citations· 41 references
Medicine
TL;DR
This study provides the first evidence demonstrating the functional role of Sema4f in cardiac fibroblast activation and fibrosis progression, and identifies a fibroblast-specific mechanism mediated by the Sema4f-actin cytoskeleton-YAP/TAZ axis, offering novel mechanistic insights into fibrosis regulation and revealing a promising therapeutic target for cardiac fibrosis with potential clinical applications.
Cardiac transcriptomic responses in zebrafish at 14 days post-cryoinjury revealed distinct transcriptome clusters corresponding to healthy and injured hearts, highlighting significant changes during cardiac regeneration.
Hong Wang, J. Paavola, S. Perttunen et al.· Basic Research in Cardiology· 0 citations
ERIO is a safe, effective natural flavonoid with promising preclinical efficacy, suggesting its potential clinical translation for myocardial fibrosis and offering new therapeutic targets to prevent heart failure progression.
Yu-Ting Liu, Yan Che, Yazhi Ding et al.· British Journal of Pharmacol...· 0 citations
In vivo injection of a PANX1 blocker provides evidence for the role of Panx1 in alleviating cardiac fibrosis and bioinformatics analysis suggests that this process is associated with the JAK/STAT signaling pathway.
Lieyang Qin, Yunjing Zhang, Diyaerjiang Aierken et al.· Acta Biochimica et Biophysic...· 0 citations
A role for FAP in cardiac fibroblast activation is supported and its induction to altered ER-phagy-related proteostasis and ER stress is linked to altered ER-phagy-related proteostasis and ER stress.
Hong-Ju Huang, Qing-Shan Yang, Zhen-fang Zhou et al.· Biochemical and Biophysical...· 1 citation
Hypertension-induced cardiac fibrosis is a major risk factor for heart failure; although disrupted mitochondrial homeostasis has been confirmed to serve a critical role in the pathological process, its upstream regulatory factors remain incompletely understood. In the current study, RNA sequencing and bioinformatics an...
Yong-Bo Ma, Xiao-Zhe Chen, Zi-Xian Liu et al.· Molecular Medicine Reports· 0 citations
It is demonstrated that loss of Smyd5 induces rapid progression to heart failure accompanied by robust inflammatory activation, including a ∼100-fold increase in Il-6 expression, accompanied by rapid progression of cardiac remodeling and heart failure.
R. Bia, Samuel M. Hickenlooper, Mickey R. Miller et al.· bioRxiv· 0 citations
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