TL;DR
OA is established as a striatal neuromodulator that interacts with other neurotransmitter systems and preferentially potentiates direct-pathway transmission, with major relevance to Parkinson's disease and other movement disorders.
It is argued that, under contemporary conditions characterized by chronic stress and extended lifespan, the purinergic signaling system may undergo a shift from predominantly acute to chronic engagement and promote maladaptive purinergic activity, contributing to its involvement in synaptic dysfunction, neuroinflammati...
It is reported that loss of nrx-1 increases the release of multiple NPs from cholinergic motor neurons in C. elegans and found that neurexins can regulate NP signaling, a novel mechanism to modify circuits and behaviors, and of potential importance for NRXN1 associated human conditions.
3,4-dihydroxyphenethylamine, commonly known as dopamine (DA), is a neuromodulator that fine-tunes neuronal excitability, neurotransmitter release, and the effects of other neurotransmitters on postsynaptic neurons. DA, acting on D1 and D2 receptor families, is involved in myriad functions. In the striatum, it is mainly...
It is demonstrated that dopaminergic modulation of astrocytes plays a key role in modulating SNr circuits and motor behavior.
The serotonin 2A receptor (5-HT2A) is a Gq/11-coupled receptor implicated in reward processing, neuropsychiatric disorders, and the actions of serotonergic psychedelics. Although 5-HT2A activation has been shown to engage endocannabinoid (eCB) signaling in several brain regions, its role in inhibitory synaptic plastici...
Metaplastic changes driven by prenatal cannabinoid exposure (PCE) on eCB signaling at excitatory afferents on dopamine neurons are identified and include a switch in retrograde signaling favoring de novo synthesis of nitric oxide (NO) to replace the actions of eCBs, which are compromised at excitatory inputs.
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