Aug 2026· Stem Cell Reviews and Reports· 0 citations· 112 references
Medicine
TL;DR
A paradigm shift from conventional cell therapies to MSC-EV-centric, cell-free strategies, which overcome traditional transplantation limitations like low engraftment and immunogenicity are proposed, establishing MSC-EVs as a next-generation therapeutic framework, guiding future clinical translation in regenerative urology.
Neurodegenerative diseases are a spectrum of progressive disorders unified by chronic neuroinflammation, oxidative and mitochondrial stress, and accumulation of misfolded proteins that ultimately drive neuronal dysfunction and loss. Despite recurring convergence on these pathogenic processes, therapeutic progress has r...
Gunjan Bawne, M. Lorenowicz· Extracellular Vesicles and C...· 0 citations
Mesenchymal stromal/stem cell-derived extracellular vesicles (MSC-EVs), including preparations frequently described as exosomes, are being investigated as cell-free candidates for tissue repair. These lipid-bilayer-delimited particles carry proteins, lipids, and nucleic acids that may modulate immune responses, cell su...
Mesenchymal stem/stromal cells (MSCs) continue to drive innovation in regenerative medicine, yet the field is undergoing a critical evolution from the early concept of cellular engraftment to complex paracrine-mediated tissue repair. This review systematically evaluates the core scientific questions defining this trans...
Man-Jin Zhang, Zheng-Shi Li, Xin-Yu Liu et al.· Science Bulletin· 0 citations
Spinal cord injury (SCI) is a severe neurological condition often leading to enduring motor, sensory, and autonomic dysfunction. Its pathophysiology involves primary mechanical damage followed by secondary injury processes including axonal disruption, demyelination, excitotoxicity, neuroinflammation, vascular dysfuncti...
Jie Yan, Can-Can Wang, Jing-Han Wang et al.· Current Stem Cell Research &...· 0 citations
A cohesive translational roadmap should combine Good Manufacturing Practice (GMP)-compliant production and mechanism-relevant potency testing with the 2025 International Society for Cell & Gene Therapy (ISCT) reporting framework.
Sacha Krolow e Silva, Iris Virgínia Rondanine Sanches, Juliana Soares Lara de Lima et al.· EXCLI Journal : Experimental...· 0 citations
Abstract Exosomes are nanoscale vesicles abundantly distributed across biological fluids, serving as crucial mediators of intercellular communication by carrying bioactive molecules such as proteins, nucleic acids, and lipids. They exert pivotal functions in various physiological and pathological processes. Mesenchymal...
Ming-Tai Chen, Zhen-Xun Wan, Yuan-Yuan Li et al.· Journal of Inflammation Rese...· 0 citations
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