Skip to content

In silico pharmacological evaluation of a multi-epitope vaccine candidate targeting the G1 and G2 glycoproteins of Oropouche virus via TLR3 interaction.

Aug 2026 · Naunyn-Schmiedeberg's Archives of Pharmacology · 0 citations · 47 references
Medicine

TL;DR

Findings indicate that the G1-based multi-epitope vaccine is a potential candidate for further experimental validation and may serve as an effective preventive strategy against OROV infection.

View source

Similar papers

Open access Sep 2026

Immunoinformatics-guided design and in silico evaluation of BAFF- and APRIL-adjuvanted multi-epitope vaccine candidates against human metapneumovirus

An immunoinformatics-guided reverse vaccinology approach to design novel BAFF- and APRIL-adjuvanted multi-epitope vaccine candidates against HMPV identified BAFF- and APRIL-containing multi-epitope constructs with favorable predicted antigenic, physicochemical, structural, and immunological characteristics that warrant...

Reham M. Alahmadi, M. Awadalla, Halah Z. Al-Rawi et al. · 0 citations
Open access Sep 2026

Design and Evaluation of a Multi-Epitope Vaccine Targeting Conserved Envelope and NS5 Proteins of Usutu Virus Using Immunoinformatics

An integrated reverse vaccinology strategy is used to identify conserved immunogenic regions from the Envelope protein and NS5 protein, and construct a multi-epitope vaccine for Usutu virus, predicting enhanced humoral and cellular immune-response patterns following repeated antigen administration.

Reem Alromaihi, H. Alharbi, S. Almerdasi et al. · 0 citations
Open access Sep 2026

In silico design of a multi-epitope mRNA vaccine candidate against rift valley fever virus using integrative immunoinformatics approaches

Rift Valley fever virus (RVFV) is a major zoonotic pathogen causing significant outbreaks in humans and livestock, with no licensed effective vaccines currently available and reverse vaccinology and immunoinformatics approaches were employed to design three multi-epitope mRNA vaccine candidates against RVFV.

E. K. Oladipo, James Akinwumi Ogunniran, Biobele Winner Sokari et al. · 0 citations
Open access Aug 2026

In Silico design and evaluation of a multi-epitope vaccine candidate against Toxoplasma gondii for humans

The rationally designed multi-epitope vaccine demonstrates robust theoretical potential to elicit comprehensive, long-lasting immunity in humans, although its safety and effectiveness require additional experimental validation.

Chenchen Yi, Yu Shen, Ye Luo et al. · 0 citations
Open access Sep 2026

Computationally guided multi-epitope vaccine design targeting oncoprotein BZLF1, EBNA1, LMP1, and LMP2 for of EBV associated gastric cancer

Epstein–Barr virus (EBV)–associated gastric cancer (EBVaGC) is distinct molecular subtype of gastric cancer for which effective preventive and targeted therapeutic strategies remain limited. This study aimed to design and evaluate multiepitope vaccine candidates targeting four EBV proteins critically involved in this d...

Elvin Delonio, Y. Ysrafil, Herlina Eka Shinta et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.