In silico pharmacological evaluation of a multi-epitope vaccine candidate targeting the G1 and G2 glycoproteins of Oropouche virus via TLR3 interaction.
Aug 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 47 references
Medicine
TL;DR
Findings indicate that the G1-based multi-epitope vaccine is a potential candidate for further experimental validation and may serve as an effective preventive strategy against OROV infection.
An immunoinformatics-guided reverse vaccinology approach to design novel BAFF- and APRIL-adjuvanted multi-epitope vaccine candidates against HMPV identified BAFF- and APRIL-containing multi-epitope constructs with favorable predicted antigenic, physicochemical, structural, and immunological characteristics that warrant...
Reham M. Alahmadi, M. Awadalla, Halah Z. Al-Rawi et al.· Frontiers in Virology· 0 citations
An integrated reverse vaccinology strategy is used to identify conserved immunogenic regions from the Envelope protein and NS5 protein, and construct a multi-epitope vaccine for Usutu virus, predicting enhanced humoral and cellular immune-response patterns following repeated antigen administration.
Reem Alromaihi, H. Alharbi, S. Almerdasi et al.· Microorganisms· 0 citations
Rift Valley fever virus (RVFV) is a major zoonotic pathogen causing significant outbreaks in humans and livestock, with no licensed effective vaccines currently available and reverse vaccinology and immunoinformatics approaches were employed to design three multi-epitope mRNA vaccine candidates against RVFV.
E. K. Oladipo, James Akinwumi Ogunniran, Biobele Winner Sokari et al.· Discover Immunity· 0 citations
The rationally designed multi-epitope vaccine demonstrates robust theoretical potential to elicit comprehensive, long-lasting immunity in humans, although its safety and effectiveness require additional experimental validation.
Chenchen Yi, Yu Shen, Ye Luo et al.· Frontiers in Cellular and In...· 0 citations
Epstein–Barr virus (EBV)–associated gastric cancer (EBVaGC) is distinct molecular subtype of gastric cancer for which effective preventive and targeted therapeutic strategies remain limited. This study aimed to design and evaluate multiepitope vaccine candidates targeting four EBV proteins critically involved in this d...
Elvin Delonio, Y. Ysrafil, Herlina Eka Shinta et al.· Journal of the Egyptian Nati...· 0 citations
The proposed multi-epitope vaccine shows promising immunological and structural properties, supporting its potential against S. typhimurium, pending experimental validation.
Mohammed Naveez Valathoor, A. P. Rajan· Scientific Reports· 0 citations
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