Aug 2026· Archives of Virology· Vol 171· 0 citations· 41 references
Medicine
TL;DR
This study characterizes Dp49, a newly discovered bacteriophage-derived depolymerase exhibiting potent enzymatic activity against bacterial exopolysaccharides and anti-biofilm activity, which demonstrates therapeutic potential by enhancing serum-mediated bactericidal activity and anti-biofilm activity.
Backgroud Carbapenem-resistant Acinetobacter baumannii (CRAB) has become a predominant nosocomial pathogen worldwide, with biofilm formation and quorum sensing (QS) primarily responsible for its high antimicrobial tolerance and clinical refractory infections. Targeting bacterial virulence rather than conventional bacte...
Bin Liu, Cai-Hua Li, Yi-Zhen Zhu et al.· Frontiers in Microbiology· 0 citations
It is suggested that vB_Kp_H122 may have potential as an antibacterial candidate against K57 MDR‐hvKP isolates, a novel lytic phage that specifically targets K57 capsular‐type MDR‐hvKP.
Cuilong Fan, Qiu Xu, S. Schwarz et al.· Transboundary and Emerging D...· 0 citations
The results indicate the multifactorial nature of Anb pathogenicity and the current limitations of knowledge of its VFs, however, the presence of numerous VFs suggests a capacity to cause disease, particularly in vulnerable host populations such as neonates.
Subhasree Roy, Daichi Morita, Tanusree Das et al.· Frontiers in Microbiology· 0 citations
Introduction Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a global health threat due to limited therapeutic options. Cefiderocol, a novel siderophore-conjugated cephalosporin, demonstrates potent in vitro activity against a variety of Gram-negative bacteria, including CRAB. However, cefiderocol's recent in...
Xiao-Chen Liu, Qing-Ye Xu, Jin-Tao He et al.· Frontiers in Microbiology· 0 citations
Acinetobacter baumannii presents a severe clinical challenge in critical care due to its rapid acquisition of drug resistance and its ability to form dense biofilms on medical equipment. While traditional antibiotic research focuses almost exclusively on essential bacterial viability targets, targeting virulence factor...
N. S. Faris, Omar Hadieh, Mohammad M. Hadieh· International Journal of Hea...· 0 citations
The isolation and characterization of three bacteriophages active against MDR A. baumannii highlight the feasibility of isolating lytic phages from environmental sources and support further investigation of bacteriophage therapy as a complementary strategy to address infections caused by multidrug-resistant pathogens.
Souradeep Chowdhury, N. Rathor, M. Soneja et al.· Le infezioni in medicina· 0 citations
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