It is demonstrated that adipose-derived ECM hydrogel loaded with cytokine-releasing microspheres provides a multifunctional therapeutic strategy that attenuates inflammation, apoptosis, oxidative stress, and ferroptosis, ultimately promoting structural and functional recovery following spinal cord injury.
BACKGROUND
Spinal cord injury (SCI) triggers oxidative stress, inflammation, and progressive neurodegeneration.
METHODS
Here, we developed a dual-therapy composite hydrogel that integrates niraparib-loaded chitosan nanoparticles (NICNPs) and adipose-derived stromal cells (ASCs) into a calcium alginate scaffold for su...
Hai-Bo Pei, Yun-Fei He, Saman Jalili· International Journal of Art...· 0 citations
Spinal cord injury (SCI) is a severe traumatic disorder of the central nervous system that results in substantial motor and sensory dysfunction. The hostile post-injury microenvironment, marked by excessive oxidative stress, inflammatory responses, and progressive neuronal degeneration, greatly limits neural repair. In...
Xing-Yu Zhu, Zhong-Hua Liu, Ke-Wei Li et al.· Advanced Healthcare Material...· 0 citations
A pH-responsive CEC/PEG-(CHO)2 hydrogel scaffold was engineered for local delivery of neuropeptide S (NPS) to modulate the hostile microenvironment after spinal cord injury (SCI). The scaffold exhibited accelerated degradation under acidic conditions mimicking the injured site, enabling controlled release of NPS. Its p...
Bai Xu, Meng-Dan Cheng, Yan Gao et al.· Frontiers in Neuroscience· 0 citations
In vitro studies showed that the hybrid scaffold promoted endothelial cell migration, supported endothelial cell growth, and maintained angiogenic activity under oxygen-glucose deprivation (OGD) conditions, which is promising for recovery after ischemic injury.
Kai-Qin Mo, Li Ruan, Wen-Zhe Du et al.· Materials and Interfaces· 0 citations
Spinal cord injury (SCI) is a devastating neurological disorder characterized by excessive neuroinflammation and limited regenerative capacity. Here, we developed a reactive oxygen species (ROS)-responsive hydrogel for localized delivery of liposomal indole-3-propionic acid (IPA), a gut microbiota-derived metabolite wi...
Long-Yu Li, Yu-Hao Zhang, Zhi-Shuo Wang et al.· Materials Today Bio· 0 citations
Diabetic wounds remain a complex clinical challenge due to impaired angiogenesis, prolonged inflammation, excessive oxidative stress, and defective extracellular matrix (ECM) remodeling. Biomaterial-based approaches that can simultaneously regulate these pathological events are highly desirable for promoting functional...
A. Hjazi· Tissue & Cell· 0 citations
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