TL;DR
The findings emphasise the importance of lipid metabolism and mitochondrial energy pathways in the pathophysiology of BD, while also highlighting the influence of mood state.
This pilot study annotated exploratory urinary metabolic alterations in treated patients with BD during a manic episode, and revealed a statistically significant but modest group-related metabolic difference, with limited discriminatory performance in OPLS-DA modelling.
Objective: Differentiating bipolar depression (BPD) from unipolar depression (UPD) remains a clinical challenge. This study aimed to compare inflammatory and metabolic parameters among hospitalized patients with UPD, BPD, and bipolar mania (BPM), and to evaluate potential biological differences between UPD and BPD.Mate...
This study suggests that BD patients present significant differences in gene expression patterns compared to healthy controls, and pathway analyses suggest that protein misfolding and endoplasmic reticulum alterations could be implicated in the pathophysiology of BD, while response to lithium might be related to modula...
Background Major depressive disorder (MDD) is increasingly recognized as a systemic condition accompanied by metabolic disturbances, particularly in lipid metabolism. However, whether MDD is associated with the development of chronic pancreatitis (CP), a chronic inflammatory disease with substantial metabolic and nutri...
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