Understanding Protein-DNA Interactions by Paying Attention to Protein and Genomics Foundation Models

D. Rajwade Erica Wang Aryan Satpathy Alexander Brace Hongyu Guo Arvind Ramanathan Shengchao Liu Anima Anandkumar NA Encoder Gpn

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TL;DR

This work proposes Seq2Contact, a novel method to predict the protein-NA binding at a single nucleotide (DNA) and single amino acid (Protein) level, which is computationally more efficient, with up to 80% less memory cost and more than 90% less inference time.

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