Skip to content

Similar papers

#protein folding Open access Sep 2026

Characterisation of an evolutionarily conserved RNaseH-like domain in a domesticated transposase-derived protein

The RNase-H fold is an ancient protein fold found in diverse nucleases that is characterised by a conserved structural core (five β strands and ⍺ helices), canonical DDE/D catalytic residues and catalytic mechanism. This study focuses on the evolutionary conservation of the RNaseH-like domain in the transposase-derived...

Aditi Saha, S. Majumdar · 0 citations
Open access Aug 2026

Evolutionarily distinct binding of amino-terminal hotspots of the human THAP protein family and its homologs

The THAP (Thanatos-associated protein) domain is a DNA-binding domain which binds DNA via a zinc-coordinating C2CH motif. Although THAP domains share a conserved structural fold, they bind different DNA sequences in different THAP proteins which in turn perform distinct cellular functions. In this study, we investigate...

Hiral M. Sanghavi, Gautam Sah · 0 citations
Open access Sep 2026

The eumetazoan origin of PRDM9 function revealed by cnidarian genome analysis

Where recombination takes place is crucial as it determines the position of genetic reshuffling, which facilitates species evolution and adaptation. In many vertebrates, PRDM9 determines the location of double-strand breaks that initiates meiotic recombination. However, this only applies for Prdm9 orthologs that posses...

Amélie Rudler, Laurent Duret, C. Grunau et al. · 0 citations
#protein folding Open access Sep 2026

Crystal Structure of the Ancient Domain of Chicken IMPACT Reveals an Evolutionarily Conserved Candidate Functional Surface in the IMPACT/YigZ Family

The crystal structure of the Ancient domain of chicken IMPACT (GgIMPACTAncient) is determined, providing the first crystallographic view of a metazoan IMPACT Ancient domain and a structural framework for testing the biochemical function of this evolutionarily conserved module.

Mirai Ido, S. Ito, T. Nishino · 0 citations
Open access Aug 2026

Gene loss propensity for metallocarboxypeptidase E in insects is shaped by structural versatility and broader expression of metallocarboxypeptidase D but not functional importance

Gene loss is a widespread phenomenon that shapes genome evolution, yet the factors determining why certain genes are repeatedly lost while other functionally related genes are retained remain poorly understood. We addressed this question using the peptide-processing metallocarboxypeptidases carboxypeptidase E (CPE) and...

Christian Wegener, Julian C. Heitkamp, Vera S. Hunnekuhl · 0 citations

Related blog posts

Google DeepMind Blog Sep 30, 2026

Introducing SynthID Bio

Proof of concept for watermarking AI-generated proteins while preserving biological function.

MIT News · Artificial Intelligence Aug 27, 2026

Looking beyond natural sequences

A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.