Open access
Feasibility of Spin‐ and Gradient‐Echo Dynamic Susceptibility Contrast MRI for Microvascular Characterization at 7 Tesla
Karen N. van der Werff
D. van Dorth
Krishnapriya Venugopal
E. Warnert
D. Poot
F. Vos
Marion Smits
Stefan Klein
C. Quarles
J. Hernández-Tamames
J. Koekkoek
J. de Bresser
M. V. van Osch
Medicine
Abstract
Perfusion MRI, especially dynamic susceptibility contrast (DSC), is vital for glioma diagnosis and monitoring. While gradient‐echo DSC is the current recommended implementation, combined spin‐ and gradient‐echo (SAGE) DSC additionally allows for vessel size imaging (VSI) and has shown feasibility for microvascular characterization at 3 T. Higher field strength MRI offers increased contrast, resolution and signal‐to‐noise ratio, providing potential to improve microvascular characterization.