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A targetable ALDH3A2-NRF2 axis mediates KEAP1-mutant tumour development via ferroptosis inhibition.

Li Yang Xiao Zhuang Jing Han Weiwei Cui Yu-Dan Zhang Zi-Qi Wang Dan-Dan Song Chao Zhou Shao-Hui Huang Kai Cui Chenchen Lin Min Xu Xingru Zhao Shuai Wang Bin Huang Hui Wang Shuang Shi Lu-Tao Du Qian-Kun Luo Qun-Cheng Zhang Zeheng Ma Cheng-Qian Yin Bo Chu Xiaoju Zhang
Aug 2026 · Cell Death and Differentiation · 0 citations · 36 references
Medicine

TL;DR

A novel NRF2 regulatory pathway is revealed and ALDH3A2 is suggested as a promising druggable target for KEAP1-mutant tumours by performing an aldehyde dehydrogenase 3 family shRNA screen.

DOI PubMed Semantic Scholar
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