Aug 2026· Research journal of biotechnology· 0 citations
TL;DR
The findings affirm that CRISPR is reshaping the landscape of plant biotechnology, offering sustainable routes for producing high-value metabolites for food, medicine and industry.
Abstract
Secondary metabolites play a pivotal role in plant
defense and human health, offering valuable
therapeutic, nutraceutical and industrial applications.
However, their natural biosynthetic pathways are often
complex, tightly regulated and yield low quantities.
Advances in genome editing particularly through
CRISPR-Cas systems have revolutionized plant
metabolic engineering, enabling precise modifications
to enhance secondary metabolite production.
This review explores recent breakthroughs in using
CRISPR tools to target key biosynthetic genes, to
regulate transcriptional networks and to rewire
metabolic flux toward desired secondary metabolites.
Specific case studies in crops such as Artemisia annua,
Atropa belladonna and tomato highlight the potential
of CRISPR-based engineering in improving yields of
artemisinin, alkaloids and carotenoids. The findings
affirm that CRISPR is reshaping the landscape of plant
biotechnology, offering sustainable routes for
producing high-value metabolites for food, medicine
and industry.
This review highlights the primary technologies used in plant metabolic engineering and focuses on representative examples of their implementation for crop improvement, including but not limited to CRISPR-Cas systems, multiplex genome editing, knock-in and knock-out strategies, CRISPR-mediated gene regulation, base edi...
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