TL;DR
A Python toolset with an agentic, code-free workspace interface called NeuroGraphBench (NGB), which automates tedious and repetitive tasks to enable faster and scalable connectomic exploration, keeping human reasoning at the center of an open-ended research inquiry.
Connectomes have emerged as foundational hub datasets that organize diverse streams of neuroscientific evidence and provide an increasingly important framework for advancing a mechanistic understanding of brain function and dysfunction.
In recent decades, the early olfactory system (EOS) of the fruit fly has become a leading model for studying olfactory processing and associative memory, owing in part to a well-characterized feedforward pathway that feeds the processes underlying associative memory and by examining the role played by a handful of neur...
FlyWire connectome-constrained whole-brain model is fitted to calcium recordings of spontaneous activity in head-fixed Drosophila, showing that spontaneous activity is not distributed uniformly across the connectome, but is organized by a compact neuropil core.
Connectomics is used to map the cell types and synaptic connections underlying a form of multi-layer continual learning that cancels predictable sensory responses in a cerebellum-like structure in electric fish, highlighting the potential of connectomics, in combination with cell-type-specific physiological recordings...
WTR, a fusion protein of mammalian codon-optimized WGA, TEV-protease cleavage sequence, and Recombinase, is developed and utilized to characterize downstream neurons of either glutamatergic or GABAergic neurons in the preoptic area of anterior hypothalamus for their differential actions in thermoregulation or stress re...
Scores of chromosome-scale loops, or metaloops, arise in the Drosophila brain, but their spatial organization and relationship to neural gene expression patterns remain unclear. Here, we used multiplexed Optical Reconstruction of Chromatin Architecture (ORCA) to examine the multiscale spatial organization of metaloops...
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