Three adult male patients with childhood‐onset ADHD and chronic tic symptoms who showed a rapid and significant improvement in tics with low‐dose extended‐release guanfacine (GXR) monotherapy suggest that GXR can effectively treat both ADHD and tic symptoms in adults.
Abstract
Tic disorders typically begin in childhood and often improve by adulthood, but some individuals continue to experience tic symptoms into adult life. Tic disorders frequently co‐occur with Attention‐deficit/hyperactivity disorder (ADHD), and in such cases α2‐adrenergic agonists are recommended as a treatment as they can address both conditions. However, evidence in adults with ADHD and comorbid tic disorders is limited, as most studies have focused on pediatric populations. Here, we present three adult male patients with childhood‐onset ADHD and chronic tic symptoms who showed a rapid and significant improvement in tics with low‐dose extended‐release guanfacine (GXR) monotherapy. These cases suggest that GXR can effectively treat both ADHD and tic symptoms in adults—a finding that has not been well documented in prior adult studies.
Key Points Question Do demographic, clinical, and genetic profiles of adults diagnosed with attention-deficit/hyperactivity disorder (ADHD) in adulthood differ from adults diagnosed with ADHD in childhood or adolescence, and how do profiles of both groups compare with matched controls without ADHD? Findings In this cro...
D. Leffa, Guilherme Bauer-Negrini, B. Bellaver et al.· JAMA Network Open· 0 citations
Purpose: Attention-deficit/hyperactivity disorder (ADHD) is among the most common comorbidities of epilepsy. Children with epilepsy are at increased risk of cognitive and behavioral problems that can impair school performance and peer relationships, particularly when ADHD is also pres-ent. Effective treatment of ADHD s...
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M. Kaczorek, Bożena Kiełbasa, Olga Kowalczyk et al.· International Journal of Inn...· 0 citations
Attention-Deficit/Hyperactivity Disorder (ADHD) is a chronic neurobiological condition that affects 5% to 7% of children and persists into adulthood in approximately 75% of cases, often accompanied by comorbidities. Its neurobiology involves dopaminergic and noradrenergic dysfunction in the corticostriatal and frontoce...
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After completing this activity, participants should be able to: Apply a two-step approach to ADHD case finding in adults entering addiction treatment, using a validated screener such as the ASRS Part A followed by a clinical assessment that leans on childhood and drug-free-period history rather than a current symptom p...
Abstract Background Tourette Syndrome (TS) is defined by motor and vocal tics that begin in childhood and persist for over a year. TS causes difficulties in daily life and lowers self‐esteem, yet pharmacological treatment options for TS remain limited. Tipepidine, administered in this case report, is generally used as...
Masumi Tachibana, Tsuyoshi Sasaki· Psychiatry and Clinical Neur...· 0 citations
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