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Review

Genetic and biological mechanisms of pediatric enuresis: integrating pathophysiology, GWAS associations, and multi-omics research

Pei Wu Jia Chen Zhu Chen
Jul 2026 · European Journal of Pediatrics · Vol 185 · 0 citations · 57 references
Medicine

TL;DR

This review provides the first comprehensive integration of pediatric enuresis pathophysiology with recent GWAS findings and emerging multi-omics data, framing the disorder within a systems biology “brain–bladder–kidney axis” model and lays the conceptual foundation for precision pediatrics approaches.

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